It is a potent and specific inhibitor of nuclear transcription factor, nf. Cape increases the expression of several antimicrobial proteins involved in the immune response to c. Caffeic acid phenethyl ester cape has been used to determine the effect of cape in hyperthyroidism, as a component of culture media to measure the cytotoxicity of breast cancer cell line mdamb231, to study its effects on amiodaroneinduced pulmonary fibrosis in rats. Caffeic acid phenethyl ester cape is a component of propolis. Caffeic acid phenethyl ester reduces ischemiainduced kidney. These compounds act on target cells by binding to estrogen receptors, er. It is also termed as phenylethyl ca eate or phenethyl ca eate. B inhibitor from honeybee propolis has been shown to have antitumor and antiinflammatory properties. Caffeic acid phenethyl ester attenuates proinflammatory. Caffeic acid phenethyl ester attenuates proinflammatory and fibrogenic phenotypes of lpsstimulated hepatic stellate cells through the inhibition of nf.
Cape derives from honeybee propolis and has several biological activities. Using the wholecell patch clamp configuration, we found that cape depolarized the pacemaker potentials of cultured iccs from the murine small intestine in a dosedependent manner. Heme oxygenase1 ho1 is a redoxsensitive inducible protein that provides efficient cytoprotection against oxidative stress. Caffeic acid 3,4dihydroxycinnamic acid is an organic compound and a potent antioxidant. Nov 30, 2007 caffeic acid phenyl ester cape, a biologically active ingredient of propolis, has several interesting biological properties including antioxidant, antiinflammatory, antiviral, immunostimulatory, antiangiogenic, antiinvasive, antimetastatic and carcinostatic activities. In this study, we investigated the effects of caffeic acid phenethyl ester cape on the pacemaker potentials of iccs from the mouse small or large intestine.
Structure of caffeic acid phenethyl ester cape cape is chemopreventive against intestinal, colon and skin cancer, and also has been shown to decreases the formation of preneoplastic hepatic lesions when is administrated in a rat model of liver carcinogenesis 1921, but the mechanism of these properties is not completely understood recently, cape, in a. You are viewing an interactive 3d depiction of the molecule caffeic acid phenethyl ester c17h16o4 from the pqr. Compounds 1 and 20 exhibited stronger cytoprotective activities than their parent. Caffeic acid phenethyl ester induces mitochondriamediated. Caffeic acid phenethyl ester cape is an antiinflammatory component of propolis honeybee resin. Xuanethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting tlr4 signal pathway and inducing apoptosis and autophagy. Curcumin, a polyphenolic natural compound that possesses antitumor and antiinflammatory properties, has been reported recently to induce potently ho1 expression in vascular endothelial cells free rad biol med 28. See below for a comprehensive list of adverse effects. Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester cape administration in pentylenetetrazole ptzinduced seizure in mice. Synthesis of caffeic acid phenethyl ester derivatives, and.
Caffeic acid phenethyl ester cape is a natural phenolic chemical compound. For this reason, we used cape in the current study. Caffeic acid phenethyl ester cape is the main polyphenol. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor nf. It is also a component of propolis from honeybee hives potential pharmacology. Salicylic acid benzyl ester an overview sciencedirect topics. Caffeic acid phenethyl ester exerts a neuroprotective effect. Caffeic acid phenethyl ester cape, an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its.
Activity of caffeic acid phenethyl ester in caenorhabditis. Signal transducer and activator of transcription protein 1 stat1, a transcription factor involved in inflammation and the. The first part of the reaction was the diacetylation of caffeic acid salt produce diacetylcaffeic acid. Usa 93 9090 if you know of a relevant reference for caffeic acid phenethyl ester, please let us know. The proposed threestep synthesis describes the total synthesis of the caffeic acid phenethyl ester cape, a potent 5lipoxygenase inhibitor from honeybee hives. Caffeic acid phenethyl ester increases radiosensitivity of estrogen receptor positive and negative breast cancer cells by prolonging. Antimicrobial activities of caffeic acid phenethyl ester. Ca eic acid phenethyl ester cape is a natural bioactive compound. Pe comprises a complex of chemicals and has been found to have various biological activities. Caffeic acid phenethyl ester, an inhibitor of nuclear factor. Review article caffeic acid phenethyl ester and therapeutic. It is the ester of caffeic acid and phenethyl alcohol natural occurrences. Caffeic acid phenethyl ester cape is a strong antioxidant extracted from honeybee hive propolis.
Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. Commonly reported side effects of estradiol include. Caffeic acid phenethyl ester is a potent and specific inhibitor of. Caffeic acid phenethyl ester, an active component of. Twentyone caffeic acid phenethyl ester cape derivatives were synthesized, and characterized by ir, hrms, 1h and c nmr analyses. Despite wide range of biological activities of cape, detailed biochemical mechanisms of its action at the level of mitochondria during ischemia are poorly described and need to be. It is acquired from propolis obtained through extraction from honeybee hives. Recently, several groups have reported that cape is cytotoxic to tumor cells but not to normal. Caffeic acid phenylethyl ester is an active component of propolis from honeybee hives. Recent studies indicate that cape treatment suppresses tumor growth and akt signaling in human prostate cancer cells. It can be found naturally in a wide range of plants. Parchem is open and ready to supply materials 18002823982 read more. Cytoprotective effect of caffeic acid phenethyl ester cape and catechol.
Caffeic acid phenethyl ester increases radiosensitivity of estrogen. Caffeic acid phenethyl ester suppressed growth and metastasis of. Depolarization of pacemaker potentials by caffeic acid. Enzymatic synthesis of caffeic acid phenethyl ester. Caffeic acid phenethyl ester cape is one of the main medicinal components of propolis. Depolarization of pacemaker potentials by caffeic acid phenethyl. All compounds were evaluated for their cytoprotective effects against h2o2induced cytotoxicity and neuritogenic activities in the neurite outgrowth in pc12 cells. Effects of caffeic acid phenethyl ester on oxidative stress. Depolarization of pacemaker potentials by caffeic acid phenethyl ester in interstitial cells of cajal from the murine small intestine. Natarajan et al 1996 caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor nf. In this study, we investigated the effects of caffeic acid phenethyl ester cape, one of the main medicinal components of propolis, on the pro.
Warning this product is not for human or veterinary use. E33,4dihydroxyphenyl2propenoic acid, 2phenylethyl ester synonyms. Recently, several groups have reported that cape is cytotoxic to tumor cells but not to normal cells. It inhibits nfkb, the lipoxygenase pathway during inflammation, and hiv1 integrase. Caffeic acid phenethyl ester, an active component of honeybee. Caffeic acid phenethyl ester, a promising component of propolis with. Research paper molecular characterization and enhancement of. Cape is a strong antioxidant 26,27 and a lipophilic derivative of caffeic acid and a phenolic antioxidant structurally related to 3,4dihydroxycinnamic acid.
In this study, we investigated the effect of cape on the regulation of ranklinduced osteoclastogenesis, bone resorption and signaling pathways. Aug 10, 2017 caffeic acid 3,4dihydroxycinnamic acid is an organic compound and a potent antioxidant. Ethyl caffeate suppresses nfkappab activation and its downstream inflammatory mediators, inos, cox2 and pge2 in vitro or in mouse skin. Application caffeic acid phenethyl ester cape has been used to determine the effect of cape in hyperthyroidism, as a component of culture media to measure the cytotoxicity of breast cancer cell line mdamb231, to study its effects on amiodaroneinduced pulmonary fibrosis in rats. Caffeic acid phenethyl ester cape is considered as one of the most active components of propolis extract pe, a natural product obtained from beehives. The effects of cape antimicrobial, antiinflammatory, immunomodulatory, antimutagenic and antioxidant have been revealed in several studies 17. Structure of caffeic acid phenethyl ester cape cape is chemopreventive against intestinal, colon and skin cancer, and also has been shown to decreases the formation of preneoplastic hepatic lesions when is administrated in a rat model of liver carcinogenesis 1921, but the mechanism of these properties is not completely understood. Caffeic acid phenethyl ester cape is a key component in new zealand propolis, known for a variety of health promoting and ther apeutic potentials. Caffeic acid phenyl ester cape, a biologically active ingredient of propolis, has several interesting biological properties including antioxidant, antiinflammatory, antiviral, immunostimulatory, antiangiogenic, antiinvasive, antimetastatic and carcinostatic activities. Caffeic acid phenethyl ester synergistically enhances. Caffeic acid phenethyl ester cape is an inhibitor of nf.
This could mean the prevention of further tumor growth of individuals with nf1 or nf2. Caffeic acid 3,4dihydroxycinnamic acid phenethyl ester cape, the major constituent of propolis, is able to increase the survival of the nematode caenorhabditis elegans after infection with the fungal pathogen candida albicans. Structure, properties, spectra, suppliers and links for. Caffeic acid phenethyl ester, caffeic acid phenethyl ester supplier, caffeic acid phenethyl ester distributor, cas 104594709, caffeic acid phenethyl ester manufacturer, caffeic acid phenethyl ester wholesale. Cape is a strong antioxidant 26, 27 and a lipophilic derivative of caffeic acid and a phenolic antioxidant structurally related to 3,4dihydroxycinnamic acid. A variety of in vitro pharmacology and effects in animal models have been reported for cape, but their clinical. In this study, the effect of caffeic acid phenethyl ester cape, the most extensively studied components in propolis, on the functions of human monocytederived dendritic cells modcs. Caffeic acid phenethyl ester, a component of beehive propolis, is a. Regulation of apoptosis, invasion and angiogenesis of. It is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal components of woody plant biomass and its residues.
Propolis, an ancient herbal medicine, has been reported the beneficial effect both in asthma patients and murine model of asthma, but the mechanism was not clearly understood. When benzyl salicylate was patch tested at 2% on 50 dermatitis patients who were not. Studies are finding that bio30 propolis, a substance made from bee pollen from new zealand, is rich in vitamins, bioflavonoids, phenolic acids and esters including cape caffeic acid phenethyl ester and is an effective treatment in blocking kinase pak1. Immunomodulatory effect of caffeic acid phenethyl ester in balbc mice. It is the ester of caffeic acid and phenethyl alcohol. Studies suggest that cape has notable human health benefits, for it inhibits the activity of 5lipoxygenase 5loa key enzyme in the. Caffeic acid was found to yield much higher conversion in nonpolar solvents than in polar ones, albeit its low solubility in nonpolar solvents. Caffeic acid phenethyl ester cape is a bioactive compound of propolis extract. Caffeic acid phenethyl ester was successfully synthesized from caffeic acid and phenethyl alcohol catalyzed by novozym 435. Caffeic acid phenethyl ester attenuates proinflammatory and.
Caffeic acid phenethyl ester inhibits the progression of. Caffeic acid phenethyl ester reduces ischemiainduced. This study aimed at investigating the modulatory impact of cape on docetaxel doc and paclitaxel ptx cytotoxicity in prostate cancer cells and exploring the possible underlying mechanisms for this chemomodulation. Caffeic acid phenethyl ester cape, an active component of propolis, is one of these. Using the wholecell patchclamp configuration, we found that cape. Therapeutic potential of caffeic acid phenethyl ester cape. Oct 14, 2016 the effect of caffeic acid phenethyl ester on the functions of human monocytederived dendritic cells. Caffeic acid phenethyl ester cape and anticancer effects. Caffeic acid phenethyl ester supplier distributor cas. In u937 cells, cape inhibits the tnfdependent activ. Quantitative analysis of caffeic acid phenethyl ester in crude propolis by liquid chromatography. Caffeic acid phenethyl ester cape is an important active component of honey bee propolis that possesses a plethora of biological activities. Caffeic acid phenethyl ester and therapeutic potentials. Effects of caffeic acid phenethyl ester on oxidative.
Eric ej927036 natural product total synthesis in the. Cape was discussed for its antiinflammatory and antioxidant properties on endothelial cells ecs. B, attenuates bacterial peptidoglycan polysaccharideinduced colitis in rats. Caffeic acid phenethyl ester supplier cas 104594709. This yellow solid consists of both phenolic and acrylic functional groups. Cape has been used in folk medicine as a potent antiinflammatory agent. It is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. In addition to traditional onestep organic synthesis laboratories, a multistep natural product synthesis is an interesting experiment to challenge students. Caffeic acid phenethyl ester cape, a plant polyphenolic concentrated in honeybee propolis, has been found to be biologically active in a variety of pathways. Quantitative analysis of caffeic acid phenethyl ester in. Caffeic acid phenethyl ester cape is the active polyphenol of propolis, a resinlike material that acts as a natural sealant in honeybee hives. Therapeutic potential of caffeic acid phenethyl ester.
Caffeic acid phenethyl ester cape is a promising component of propolis that possesses serm activity. Caffeic acid phenethyl ester is a potential therapeutic. Not for human or veterinary diagnostic or therapeutic 800 3649897use. We investigated the molecular mechanism of anticancer and anti metastasis activities of cape. Caffeic acid phenethyl ester cape, biologically active compound of propolis, might be one of the promising therapeutic agents against ischemiacaused damage. Caffeic acid phenethyl ester supplier distributor cas 104594. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor nfkappa b. The literature search elaborates that cape possesses antimicrobial, antioxidant, antiinflammatory, and cytotoxic properties. The oxygen electrons of caffeic acid, bond to the carbonyl of acetic anhydride 12. Caffeic acid phenethyl ester cape figure 1 is one of the main bioactive components extracted from honeybee hive propolis. Caffeic acid phenethyl ester exerts a neuroprotective. Mar 01, 2002 heme oxygenase1 ho1 is a redoxsensitive inducible protein that provides efficient cytoprotection against oxidative stress. Pdf caffeic acid phenethyl ester suppressed growth and. Caffeic acid phenethyl ester as a potential treatment for.
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